Scientific activities

Several years ago, the G.B. Bietti Foundation established a centre for the study and treatment of the main ocular pathologies.
These activities involve all of the Foundation’s researchers who are assigned to one of the Research Units, and thus include clinical trials for pathologies inherent to neurophthalmology, the anterior segment, glaucoma, retinal pathologies of medical and surgical interest, and ocular oncology.

Numerous international, spontaneous, and targeted clinical trials are normally carried out in this field, in order both to shed light on the pathogenetic mechanisms of the diseases with the biggest social impacts, and to study the most efficient, cutting-edge treatments for them.

The recruitment and selection of clinical trial patients is based on a careful assessment, in strict compliance with the inclusion criteria required by each individual research protocol. The results of these trials are periodically analyzed, and are often presented during academic conferences and/or published in high-impact-factor scientific journals.

The scientific activities of the G.B. Bietti Foundation IRCCS are carried out in 6 Research Units, each one having the goal of achieving results regarding the prevention, diagnosis, and treatment of specific ocular pathologies.

In particular, a study is ongoing on the role played by cells, cytokines, and growth factors in the physiopathological mechanisms of vitreoretinal rhegmatogenous pathologies and in degenerative retinopathies.

Studies on glaucoma focused principally on the mechanisms behind the loss of retinal ganglion cells and nerve fibres, and have made it possible to highlight the role played by growth factors in the neuropotential of the retinal structures involved in hypertension. Studies on animal models and on humans have made it possible to assess the histopathological, hemodynamic, and electro-physiological alterations caused by this pathology.

Research activities in the fields of corneal and conjunctival pathologies have focused on the mechanisms behind ocular inflammation and the study of reparative mechanisms of the cornea, along with corneal biomechanics and the interaction of lasers with corneal tissue in order to optimize the results of refractive surgery and cornea transplantations.

Some of these studies are ongoing, but many have already been published in leading medical and ophthalmological journals such as, for example, N. Engl. J. Med.; Proc. Natl. Acad. Sci. USA; Invest. Ophthalmol. Vis Sci.; Ophthalmology; Graefe Arch. Ophthalmol; Retina; Clinical Neurophysiology; etc.

Results

LEGAL HEADQUARTERS AND CLINICAL TRIALS CENTER
(CLINICAL TRIALS CENTER)

Via Livenza n. 3
00198 Roma
OCULAR SURFACE RESEARCH LABORATORY

CAMPUS BIO-MEDICO UNIVERSITY POLYCLINIC IN ROME

Legal Headquarters and Clinical Trials Centre
(Clinical Trials Center)
Via Livenza n. 3 - 00198 Roma
      

At this location, the G.B. Bietti Foundation IRCCS established a centre dedicated to research on the main ocular pathologies (the first such clinical trials centre in Italy), with specific Research Units:

  • Unit 1. Glaucoma - Coordinator Prof. Marco Centofanti
  • Unit 2. Medical Retina - Coordinator Prof. Monica Varano
  • Unit 3. Surgical Retina - Coordinator Dr. Guido Ripandelli
  • Unit 4. Anterior Segment and Ocular Annexes - Coordinator Dr.ssa Alessandra Micera
    • Operating Unit for Ocular Surface Research - Coordinator Dr.ssa Alessandra Micera
    • Operating Unit for Cornea and Crystalline Lens Research - Coordinator Dr. Pietro Ducoli
  • Unit 5. Ocular Oncology and Toxicology - Coordinator Prof. Edoardo Midena
  • Unit 6. Neurophysiology of Vision and Neurophthalmology - Coordinator Prof. Vincenzo Parisi

Along with the most advanced equipment for diagnosis and parasurgical therapy, the Centre also boasts a “sterile room” for intravitreal injections; a hall for scientific conferences, lessons, courses, and seminars; and a library providing both hard-copy and online access to scientific journals. Additionally, the Foundation participates in the Ministry of Health’s Bibliosan project – a library system for Italian biomedical research institutes – and is part of the GARR fiberoptic network for the exchange of data and information with other Research Hospitals, the Superior Health Institute (Istituto Superiore di Sanità), and the Ministry of Health.

Accessing the services

The patients of this Centre are recruited exclusively from clinical trials and specific research protocols, and for this reason the services provided by this Centre are free of charge and do not require a referral from a physician, since they are not at the expense of the National Health Service..

OCULAR SURFACE RESEARCH LABORATORY
Policlinico Universitario Campus Bio-Medico di Roma
Polo di ricerca avanzata in biomedicina e bioingegneria (PRABB)
Via Álvaro del Portillo n. 21 - 00128 Roma
1° floor, room 9196

The laboratory, established with the help of Fondazione Roma by the G.B. Bietti Foundation at the Centro Integrato di Ricerca (CIR) of the Campus Bio-Medico University in Rome, is endowed with state-of-the art scientific equipment for research in cell, biochemical, and molecular biology.

Director: Dr.ssa A. Micera